Fresh analysis reveals that people who stop using popular slimming jabs like Wegovy and Mounjaro can put back on reduced body mass much more quickly than those who halt conventional diet and exercise regimens.
Findings released in a major health publication shows that while obese people often shed about a fifth of their body weight while undergoing treatment, the mass comes back at an estimated rate of 0.8 kg per month once they quit.
"Individuals purchasing such medications need to be cognizant of the potential of quick weight regain when the medication is stopped," warns lead investigator Dr. Susan Jebb.
That rate of recovery means a reversion to starting weight within about 18 months.
Analyzing Approaches
The study, which examined 37 of trials involving thousands of patients, compared the effects of GLP-1 agonists with conventional dieting.
Researchers note that individuals who lose weight through dieting usually experience a less rapid weight regain—around 100 grams monthly—after stopping.
The Reason for the Quick Rebound
Experts suggest the mechanism of the jabs is key to understanding the heightened regain.
The injections copy a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Artificially providing the hormone levels far above than normal may cause the system to produce less of its endogenous hormone, and could lessen responsiveness to its effects," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication means hunger is uncontrolled, making binge eating far more likely."
A Chronic Condition?
The NHS suggest the jabs for people with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
A number of clinicians say that, given the likelihood of weight regain, the treatment might need to be long-term.
This perspective is supported by pharmaceutical companies, who say that the findings "highlight the persistent nature of obesity," similar to managing diseases like diabetes.
User Testimonies
People who have discontinued the jabs report a intense return of appetite.
"It felt as if a switch that goes on and you become ravenous," said an individual.
The struggle is compounded if users have not developed lasting dietary or behavioural modifications during therapy.
Widespread Use
Figures show that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with demand continuing to grow.
- Use is more common among women compared to males.
- The middle-aged demographic shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than the NHS.
Finally, clinicians stress that while the jabs are effective tools for weight loss, they are not a standalone solution and long-term success relies on combined behavioural management.
